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KMID : 1144720210250020076
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Investigative Magnetic Resonance Imaging
2021 Volume.25 No. 2 p.76 ~ p.80
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The Emerging Role of Fast MR Techniques in Traumatic Brain Injury
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Yoo Roh-Eul
Choi Seung-Hong
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Abstract
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Post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) is a major factor that contributes to the increased socioeconomic burden caused by TBI. Myelin loss has been implicated in the development of PCS following mTBI. Diffusion tensor imaging (DTI), a traditional imaging modality for the evaluation of axonal and myelin integrity in mTBI, has intrinsic limitations, including its lack of specificity and its time-consuming and labor-intensive post-processing analysis. More recently, various fast MR techniques based on multicomponent relaxometry (MCR), including QRAPMASTER, mcDESPOT, and MDME sequences, have been developed. These MCR-based sequences can provide myelin water fraction/myelin volume fraction, a quantitative parameter more specific to myelin, which might serve as a surrogate marker of myelin volume, in a clinically feasible time. In this review, we summarize the clinical application of the MCR-based fast MR techniques in mTBI patients.
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KEYWORD
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Post-concussion syndrome, Mild traumatic brain injury, Myelin, Diffusion tensor imaging, Multi-component relaxometry
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